In the 21st century scientists will master the basic building blocks of life. We will be able to design and remake organisms in any way we choose.
The all important question is who controls that process? Who owns the intellectual property? Who influences the legislative policy? How rigorous is the government oversight? A strain of corn modified to kill corn borers and rootworm is small peanuts compared to what is coming down the pike, and it is absolutely critical that the corporations who stand to capitalize on the introduction of radically new products are under constant scrutiny and regulation.
The most important "21st Century Skills" are political.